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Narendra Vaish's Patents and Publications


Inventor or co-inventor on 150 biotechnology patents or patent applications, including the following:


  • RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA), J. McSwiggen, Narendra Vaish, US20100145038.

  • UsiRNA complexes, M.V. Templin, Narendra K. Vaish, B.A. Polisky, M.E. Houston, WO/2010/065756.

  • Ribonucleic acids with non-standard bases and uses thereof, S.C. Quay, Narendra K. Vaish, US20100015708. 

  • Nucleic acid compounds for inhibiting MYC gene expression and uses thereof, S.C. Quay, J. McSwiggen, Narendra K. Vaish, M. Ahmadian, WO/2009/029293.

  • Detection and Quantitation of Nucleic Acid Molecules in Biological Samples, S. Radka, S. Zinnen, V. Jadhav, J. McSwiggen and Narendra K. Vaish, WO2005021800.

  • RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA), Morrissey David, J. McSwiggen, S. Zinnen, and V. Jadhav, Narendra Vaish, WO2005019453.

  • Nucleic Acid Catalysts with Endonuclease Activity. F. Eckstein, Narendra K. Vaish and P.A. Heaton, U.S.A. Patent No.  6,127,173, issued 2000.


34 peer-reviewed publications and 20 abstracts in scientific journals:

  • The Design, Synthesis and Evaluation of Highly Specific and Functional siRNA Incorporating Unlocked Nucleobase Analogs. Narendra Vaish* and P. Agarwal. Methods in Molecular Biology, 2013, 942, 111-34.

  • Pilot Trial of OnabotulinumtoxinA (Botox) in Moderate to Severe Restless Legs Syndrome. P. Agarwal, C. Sia, Narendra Vaish and I. Roy-Faderman. Int J Neurosci, 2011, 121, 622-25.

  • Restless Legs Syndrome. P. Agarwal and Narendra Vaish. Neurology Medlink. Feb 4, 2011.

  • An Amino Acid-Based Amphoteric Liposomal Delivery System for Systemic Administration of siRNA. R.C. Adami, S. Seth, P. Harvie, R. Johns, R. Fam, K. Fosnaugh, T. Zhu, K. Farber, M. McCutcheon, T.T. Goodman, Y. Liu, Y. Chen, E. Kwang, M.V. Templin, G. Severson, T. Brown, Narendra Vaish, Feng Chen, Patrick Charmley, Barry Polisky, and Michael E Houston, Jr. Molecular Therapy, 2011, 19, 1141-51.

  • RNAi-based Therapeutics Targeting Survivin and PLK1 for Treatment of Bladder Cancer. S. Seth, Y. Matsui, K. Fosnaugh, Y. Liu, Narendra Vaish, R. Adami, P. Harvie, R. Johns, G. Severson, T. Brown, A. Takagi, S. Bell, Y. Chen, F. Chen, T. Zhu, R. Fam, E. Kwang, M. McCutcheon, K. Farber, P. Charmley, M.E. Houston, A. So, M.V. Templin and Barry P. Molecular Therapy, 2011, 19, 928-35.

  • Improved specificity of Gene Silencing by siRNAs Containing Unlocked Nucleobase Analogs. Narendra Vaish*, F. Chen, S. Seth, K. Fosnaugh, Y. Liu, R. Adami, T. Brown, Y. Chen, P. Harvie, R. Johns, G. Severson, B. Granger, P. Charmley, M. Houston, M. V. Templin and B. Polisky. Nucleic Acids Res., 2011, 39, 1823-32.

  • Gabapentin Enacarbil – Clinical efficacy in RLS. P. Agarwal*, A. Griffith, R. Costantino and Narendra Vaish*. Neuropsychiatric Disease and Treatment, 2010, 6, 151-158.

  • Potent and Persistent in vivo Anti-HBV Activity of Chemically Modified siRNAs.  D.V. Morrissey, J.A. Lockridge, L. Shaw, K. Blanchard, K. Jensen, W. Breen, K. Hartsough, L. Machemer, S. Radka, V. Jadhav, Narendra K. Vaish, S. Zinnen, C. Vargeese, K. Bowman, C.S. Shaffer, L.B. Jeffs, A. Judge, I. Maclachlan and B. Polisky. Nature Biotechnology, 2005, 23, 1002-1007.

  • High-Throughput Ribozyme-Based Assays for Detection of Viral Nucleic Acids. K. Kossen, Narendra K. Vaish, V. R. Jadhav, C. Pasko, H. Wang, R. Jenison, J. A. McSwiggen, B. Polisky, S. D. Seiwert. Chemistry & Biology, 2004, 11, 807-815. 

  • Zeptomole Detection of a Viral Nucleic Acid Using a Target-activated Ribozyme. Narendra K. Vaish*, Vasant R. Jadhav, Karl Kossen, Christopher Pasko, Lori E. Andrews, James A. McSwiggen, Barry Polisky, Scott D. Seiwert*, RNA, 2003, 9, 1058-1072. 

  • Novel, Modification-dependent ATP-binding Aptamer Selected from an RNA Library Incorporating Cationic Functionality. Narendra K. Vaish, R. Larralde, A.W. Fraley, J.W. Szostak and L.W. McLaughlin, Biochemistry, 2003, 42, 8842-8851.

  • Monitoring Post-translational Modification of Proteins with Allosteric Ribozymes. Narendra K. Vaish*, F. Dong, L. Andrews, R.E. Schweppe, N.G. Ahn, L. Blatt and S.D. Seiwert*, Nature Biotechnology, 2002, 20, 810-815.

  • Expanding the Structural and Functional Diversity of RNA: Analogue Uridine Triphosphates as Candidates for in vitro Selection of Nucleic Acids. Narendra K. Vaish, A.W. Fraley, J.W. Szostak and L.W. McLaughlin, Nucleic Acids Research, 2000, 28, 3316-3322.

  • In vitro Evolution of the Hammerhead Ribozyme to a Purine-specific Ribozyme using Mutagenic PCR with two Nucleotide Analogues. A.R. Kore, Narendra K. Vaish, J.A. Morris and F. Eckstein, J. Mol. Biol., 2000, 301, 1113-1121.

  • Chemical Nucleases Crafted from Core Oxalo Retro-bispeptides. D. Ranganathan and Narendra K. Vaish, Research on Chemical Intermediates, 1999, 25, 609-614.

  • The Demonstration of Spontaneous Self-assembly of Novel Fluorescent Proflavin-lipids. D. Ranganathan, V. Haridas, Narendra K. Vaish, K.P. Madhusudanan, R. Roy, D. Balasubramanian and V. Srinivas, Journal of the Indian Chemical Society, 1998, 75, 598-600.

  • Sequence Specificity of the Hammerhead Ribozyme Revisited; The NHH Rule. A.R. Kore, Narendra K. Vaish, U. Kutzke and F. Eckstein, Nucleic Acids Res., 1998, 26, 4116-4120.

  • In vitro Selection of Purine Nucleotide Specific Hammerhead-like Ribozymes. Narendra K. Vaish, P.A. Heaton, O. Fedorova and F. Eckstein, Proc. Natl. Acad. Sci. USA, 1998, 95, 2158-2162.

  • In vitro Selection of Hammerhead Ribozymes with Altered Core Sequences. Narendra K. Vaish, P.A. Heaton and F. Eckstein, Biochemistry, 1997, 36, 6495-601.

  • Crystal Structure of [Aib-COCO-Aib]Cu2: A Unique Example of Modular Self-Assembly. D. Ranganathan, Narendra K. Vaish, G.V.R. Chandramouli, B. Verghese, R.B. Muthukumaran and P.T. Manoharan, J. Am. Chem. Soc., 1995, 117, 1643-1644.

  • Protein Backbone Modification by Novel C-C Side Chain Scission. D. Ranganathan, Narendra K. Vaish and K. Shah, J. Am. Chem. Soc., 1994, 116, 6545-6557.

  • Conformation of Oxalamide Group in Retro-bispeptides: Three Crystal Structures. I.L. Karle, D. Ranganathan, K. Shah and Narendra K. Vaish, Int. J. Peptide Protein Research, 1994, 43, 160-165.

  • Synthetic Nucleases Crafted from L-Lysine. D. Ranganathan, R.K. Misra, B.K. Patel and Narendra K. Vaish, Proc. Ind. Acad. Sci., 1994, 106, 1071-1088.

  • Oxalopeptides as Core Motifs for Protein Design. D. Ranganathan, Narendra K. Vaish, K. Shah, R. Roy and K.P. Madhusudanan, J. Chem. Soc., Chem. Commun., 1993, 92-94.

  • An Exceptionally Mild and Efficient Route to Dehydroalanine Peptides. D. Ranganathan, K. Shah and Narendra Vaish, J. Chem. Soc., Chem. Commun., 1992, 1145-1147.

  • Enzyme Action: The Delineation of Novel Strategies Based on Reaction Mechanisms and Transitions States. D. Ranganathan, F. Farooqui, R. Rathi, S. Saini, Narendra Vaish and S. George, Pure and Appl. Chem., 1992, 64, 1147-1151.

  • Enzyme Action: The Delineation of Novel Strategies Based on Reaction Mechanisms and Transitions States. D. Ranganathan, F. Farooqui, R. Rathi, S. Saini, Narendra Vaish and S. George Indian Journal of Chemistry, 1992, 31B, 930.

  • Modified Ribonucleotides and RNA. S. Verma, Narendra K. Vaish and F. Eckstein. RNA: Current Concepts, Eds. D. Söll, S. Nishimura and P.B. Moore, Comprehensive Natural Products Chemistry, 1999, Vol. 6, Chap. 6.14, pp. 217-233.

  • RNA Interference and Therapeutic Applications. Narendra K. Vaish*. Cosmetics & Toiletries, 2007, 122, 50-54.

  • Functional RNAs as Tools in Proteomics. Narendra K. Vaish* and S. Zinnen. Current Proteomics, 2005, 2, 165-178.

  • Monitoring Protein Modification with Allosteric Ribozymes.  Narendra K. Vaish*, K. Kossen, L.E. Andrews, C. Pasko, S.D. Seiwert*. Methods, 2004, 32, 428-436.  

  • Halo- and Selenolactonisation: The Two Major Strategies for Cyclofunctionalisation. S. Ranganathan, K.M. Muraleedharan, Narendra. K. Vaish and N. Jayaraman. Tetrahedron, 2004, 60, 5273-5308.

  • Recent Developments in Hammerhead Ribozyme Field. Narendra K. Vaish, A. R. Kore and F. Eckstein. Nucleic Acids. Res., 1998, 26, 5237-5242.

  • Structure-Function Studies of the Hammerhead Ribozyme. S. Verma, Narendra K. Vaish and F. Eckstein. Current Opinion in Chemical Biology, 1997, 1, 532-536.

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